The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
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منابع مشابه
The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.
During studies to extend the half-life of crystalline nanoformulated antiretroviral therapy (nanoART) the mixed lineage kinase-3 inhibitor URMC-099, developed as an adjunctive neuroprotective agent was shown to facilitate antiviral responses. Long-acting ritonavir-boosted atazanavir (nanoATV/r) nanoformulations co-administered with URMC-099 reduced viral load and the numbers of HIV-1 infected C...
متن کاملThe new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) is a significant source of disability in the HIV-infected population. Even with stringent adherence to anti-retroviral therapy, >50% of patients living with HIV-1 will develop HAND (Heaton et al., 2010). Because suppression of viral replication alone is not enough to stop HAND progression, there is a need for an adjun...
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Long-acting anti-HIV products can substantively change the standard of care for patients with HIV/AIDS. To this end, hydrophobic antiretroviral drugs (ARVs) were recently developed for parenteral administration at monthly or longer intervals. While shorter-acting hydrophilic drugs can be made into nanocarrier-encased prodrugs, the nanocarrier encasement must be boosted to establish long-acting ...
متن کاملThe E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3.
Mixed-lineage kinase 3 (MLK3) activates mitogen-activated protein kinase (MAPK) signaling pathways and has important functions in migration, invasion, proliferation, tumorigenesis, and apoptosis. We investigated the role of the E3 ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in the regulation of MLK3 protein levels. We show that CHIP interacts with MLK3 and, together with the E2...
متن کاملThe Effects of Glycogen Syntase Kinase-3 β Inhibitor on The Ostogenic Differentiation of Unrestricted Somatic Stem Cells (Ussc)
Purpose: Bone defects caused by injuries, trauma, cancer, surgical operation or joint dislocation have great impacts on general health. Considering that Wnt signalling is one of the important regulators of the stem cell control, we sought to examine if Wnt activation affects the osteogenic differentiation of the USSCs.Materials and Methods: In this study, we have treated USSCs cultured in osteo...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2016
ISSN: 1742-2094
DOI: 10.1186/s12974-016-0646-z